Although family history plays a role so does metabolic health. One of the most important drivers of disease is insulin.

The relationship between obesity and cancer can be simply stated: Obesity is related to high levels of insulin and the insulin effect is to cause inflammation, lock up fat and increase the likelihood of cancer.
This increases the amount of stored visceral fat (also known as inflammatory fat, organ fat or hard fat) which is implicated in disease and a marker of ill health. The effect of this is metabolic disease and poor mitochondrial health.