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“When ketones first came to the attention of physicians in the latter part of the 19th century, it was because they were found in abundance in the urine of patients in diabetic coma. It soon became evident that a vast overproduction of ketones in the body was largely responsible for the devastating clinical manifestations of what is now called diabetic ketoacidosis. Negative views about ketones prevailed… As analytical techniques have gained in precision and sensitivity, ketone bodies have proved to be normal components of blood, not products that appear only when the metabolism of carbohydrate is disordered.”